Exacerbation of latent lupus: is the culprit acid-fast bacilli or antitubercular therapy?
Identifieur interne : 001220 ( Main/Exploration ); précédent : 001219; suivant : 001221Exacerbation of latent lupus: is the culprit acid-fast bacilli or antitubercular therapy?
Auteurs : Harpreet Singh [Inde] ; Sucharita Ray [Inde] ; Maneet Kaur [Inde] ; Vikas Gupta [Inde] ; Harish Kumar [Inde] ; Paulomi Talapatra [Inde] ; Rekha Mathur [Inde] ; Suvrat Arya [Inde] ; Naveen Ghangas [Inde]Source :
- Clinical Rheumatology [ 0770-3198 ] ; 2013-08-01.
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Abstract
Abstract: Typical as well as atypical presentations of systemic lupus erythematosus are being increasingly recognized due to improved diagnostic methods. In a tuberculosis-endemic country like India, it was traditionally believed that the occurrence of tuberculosis in lupus was due to the chronic immunosuppression caused by lupus or because of the use of steroids or isoniazid-induced lupus. Increasingly several patients with no recorded predisposition to lupus with a history of treatment for tuberculosis are coming with evidence of systemic lupus erythematosus rather than a drug-limited story. Whether the development of an autoimmune state is a mere conjecture or the presence of acid-fast bacilli in the body for a prolonged duration causes complex antigenic interactions leading to an antigenic response needs to be looked into. We present a report of three such patients and review the pathogenetic interactions that could possibly explain the role of mycobacterial antigens as a putative antigen in the pathogenesis of lupus.
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DOI: 10.1007/s10067-013-2250-2
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D Sharma PGIMS, Rohtak, Haryana</wicri:regionArea><wicri:noRegion>Haryana</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Clinical Rheumatology</title><title level="j" type="sub">Journal of the International League of Associations for Rheumatology</title><title level="j" type="abbrev">Clin Rheumatol</title><idno type="ISSN">0770-3198</idno><idno type="eISSN">1434-9949</idno><imprint><publisher>Springer London</publisher><pubPlace>London</pubPlace><date type="published" when="2013-08-01">2013-08-01</date><biblScope unit="volume">32</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1233">1233</biblScope><biblScope unit="page" to="1236">1236</biblScope></imprint><idno type="ISSN">0770-3198</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0770-3198</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Epitope spreading</term><term>Latent lupus</term><term>Lupus</term><term>Pathogenesis</term><term>Tuberculosis</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Typical as well as atypical presentations of systemic lupus erythematosus are being increasingly recognized due to improved diagnostic methods. In a tuberculosis-endemic country like India, it was traditionally believed that the occurrence of tuberculosis in lupus was due to the chronic immunosuppression caused by lupus or because of the use of steroids or isoniazid-induced lupus. Increasingly several patients with no recorded predisposition to lupus with a history of treatment for tuberculosis are coming with evidence of systemic lupus erythematosus rather than a drug-limited story. Whether the development of an autoimmune state is a mere conjecture or the presence of acid-fast bacilli in the body for a prolonged duration causes complex antigenic interactions leading to an antigenic response needs to be looked into. We present a report of three such patients and review the pathogenetic interactions that could possibly explain the role of mycobacterial antigens as a putative antigen in the pathogenesis of lupus.</div></front></TEI><affiliations><list><country><li>Inde</li></country></list><tree><country name="Inde"><noRegion><name sortKey="Singh, Harpreet" sort="Singh, Harpreet" uniqKey="Singh H" first="Harpreet" last="Singh">Harpreet Singh</name></noRegion><name sortKey="Arya, Suvrat" sort="Arya, Suvrat" uniqKey="Arya S" first="Suvrat" last="Arya">Suvrat Arya</name><name sortKey="Ghangas, Naveen" sort="Ghangas, Naveen" uniqKey="Ghangas N" first="Naveen" last="Ghangas">Naveen Ghangas</name><name sortKey="Gupta, Vikas" sort="Gupta, Vikas" uniqKey="Gupta V" first="Vikas" last="Gupta">Vikas Gupta</name><name sortKey="Kaur, Maneet" sort="Kaur, Maneet" uniqKey="Kaur M" first="Maneet" last="Kaur">Maneet Kaur</name><name sortKey="Kumar, Harish" sort="Kumar, Harish" uniqKey="Kumar H" first="Harish" last="Kumar">Harish Kumar</name><name sortKey="Mathur, Rekha" sort="Mathur, Rekha" uniqKey="Mathur R" first="Rekha" last="Mathur">Rekha Mathur</name><name sortKey="Ray, Sucharita" sort="Ray, Sucharita" uniqKey="Ray S" first="Sucharita" last="Ray">Sucharita Ray</name><name sortKey="Talapatra, Paulomi" sort="Talapatra, Paulomi" uniqKey="Talapatra P" first="Paulomi" last="Talapatra">Paulomi Talapatra</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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